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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-4-18
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pubmed:abstractText |
We assayed aqueous humor (AH) samples from patients with Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-? and tumor necrosis factor-? and the immunosuppressive cytokine IL-10. Cytokine levels were significantly higher in the three disease groups than in controls. In patients with similar disease activity, levels of IL-15 and IFN-? were significantly higher in BD patients than in VKH and HLA-B27-associated uveitis groups. Logistic regression identified a significant negative correlation between BD and high levels of IL-10 and a significant positive correlation between VKH disease and high levels of IL-10. The proinflammatory cytokines versus IL-10 ratios were significantly higher in BD compared with other groups. These data suggest that both T helper (Th) 1 and Th17 cells are involved in endogenous uveitis immunopathogenesis. BD is characterized by extensive Th1 polarization, severe proinflammatory conditions and a low immunosuppressive status.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenal Cortex Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B27 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/IL10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1521-7035
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-84
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pubmed:meshHeading |
pubmed-meshheading:21334264-Adolescent,
pubmed-meshheading:21334264-Adrenal Cortex Hormones,
pubmed-meshheading:21334264-Adult,
pubmed-meshheading:21334264-Aqueous Humor,
pubmed-meshheading:21334264-Behcet Syndrome,
pubmed-meshheading:21334264-Cyclosporine,
pubmed-meshheading:21334264-Cytokines,
pubmed-meshheading:21334264-Female,
pubmed-meshheading:21334264-HLA-B27 Antigen,
pubmed-meshheading:21334264-Humans,
pubmed-meshheading:21334264-Interferon-gamma,
pubmed-meshheading:21334264-Interleukin-10,
pubmed-meshheading:21334264-Interleukin-15,
pubmed-meshheading:21334264-Interleukin-17,
pubmed-meshheading:21334264-Logistic Models,
pubmed-meshheading:21334264-Male,
pubmed-meshheading:21334264-Middle Aged,
pubmed-meshheading:21334264-Th1 Cells,
pubmed-meshheading:21334264-Th17 Cells,
pubmed-meshheading:21334264-Treatment Outcome,
pubmed-meshheading:21334264-Tumor Necrosis Factor-alpha,
pubmed-meshheading:21334264-Uveitis,
pubmed-meshheading:21334264-Uveomeningoencephalitic Syndrome,
pubmed-meshheading:21334264-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.
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pubmed:affiliation |
Department of Ophthalmology, King Abdulaziz University Hospital, College of Medicine, King Saud University, Old Airport Road, PO Box 245, Riyadh 11411, Saudi Arabia. abuasrar@KSU.edu.sa
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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