Linked Life Data

21334038

Source:http://linkedlifedata.com/resource/pubmed/id/21334038

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-3-18
pubmed:abstractText
Pandemic influenza viral infections have been associated with viral pneumonia. Chimeric influenza viruses with the hemagglutinin segment of the 1918, 1957, 1968, or 2009 pandemic influenza viruses in the context of a seasonal H1N1 influenza genome were constructed to analyze the role of hemagglutinin (HA) in pathogenesis and cell tropism in a mouse model. We also explored whether there was an association between the ability of lung surfactant protein D (SP-D) to bind to the HA and the ability of the corresponding chimeric virus to infect bronchiolar and alveolar epithelial cells of the lower respiratory tract. Viruses expressing the hemagglutinin of pandemic viruses were associated with significant pathology in the lower respiratory tract, including acute inflammation, and showed low binding activity for SP-D. In contrast, the virus expressing the HA of a seasonal influenza strain induced only mild disease with little lung pathology in infected mice and exhibited strong in vitro binding to SP-D.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1096-0341
pubmed:author
pubmed:copyrightInfo
Published by Elsevier Inc.
pubmed:issnType
Electronic
pubmed:day
10
pubmed:volume
412
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
426-34
pubmed:meshHeading
pubmed-meshheading:21334038-Animals, pubmed-meshheading:21334038-Body Weight, pubmed-meshheading:21334038-Disease Models, Animal, pubmed-meshheading:21334038-Epithelial Cells, pubmed-meshheading:21334038-Female, pubmed-meshheading:21334038-Hemagglutinin Glycoproteins, Influenza Virus, pubmed-meshheading:21334038-Histocytochemistry, pubmed-meshheading:21334038-Influenza A Virus, H1N1 Subtype, pubmed-meshheading:21334038-Lung, pubmed-meshheading:21334038-Mice, pubmed-meshheading:21334038-Mice, Inbred BALB C, pubmed-meshheading:21334038-Microscopy, pubmed-meshheading:21334038-Pneumonia, Viral, pubmed-meshheading:21334038-Protein Binding, pubmed-meshheading:21334038-Pulmonary Surfactant-Associated Protein D, pubmed-meshheading:21334038-Survival Analysis, pubmed-meshheading:21334038-Virulence Factors
pubmed:year
2011
pubmed:articleTitle
The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding.
pubmed:affiliation
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Intramural