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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0023981,
umls-concept:C0026336,
umls-concept:C0026549,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0086376,
umls-concept:C0205112,
umls-concept:C0221099,
umls-concept:C0233490,
umls-concept:C0439231,
umls-concept:C0441655,
umls-concept:C0751074,
umls-concept:C1706089,
umls-concept:C2700303
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|
pubmed:issue |
3
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pubmed:dateCreated |
2011-3-28
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pubmed:abstractText |
Epidemiological studies in patients with type 1 and type 2 diabetes show that hyperglycemia is associated with the development of long-term microvascular complications, including painful diabetic neuropathy (PDN). However, as the prevalence of type 2 diabetes in humans far exceeds that of type 1, the present study was undertaken as a 22-week longitudinal investigation commencing at 7 weeks of age, to assess the utility of the Zucker diabetic fatty (ZDF) rat model of type 2 diabetes for the study of PDN.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1526-4637
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pubmed:author |
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pubmed:copyrightInfo |
Wiley Periodicals, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
437-50
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pubmed:meshHeading |
pubmed-meshheading:21332939-Analgesics, Opioid,
pubmed-meshheading:21332939-Animals,
pubmed-meshheading:21332939-Behavior, Animal,
pubmed-meshheading:21332939-Blood Glucose,
pubmed-meshheading:21332939-Body Weight,
pubmed-meshheading:21332939-Diabetes Mellitus, Type 2,
pubmed-meshheading:21332939-Diabetic Neuropathies,
pubmed-meshheading:21332939-Diet,
pubmed-meshheading:21332939-Disease Models, Animal,
pubmed-meshheading:21332939-Drinking,
pubmed-meshheading:21332939-Drug Tolerance,
pubmed-meshheading:21332939-Eating,
pubmed-meshheading:21332939-GTP-Binding Proteins,
pubmed-meshheading:21332939-Humans,
pubmed-meshheading:21332939-Longitudinal Studies,
pubmed-meshheading:21332939-Male,
pubmed-meshheading:21332939-Morphine,
pubmed-meshheading:21332939-Pain Measurement,
pubmed-meshheading:21332939-Rats,
pubmed-meshheading:21332939-Rats, Zucker,
pubmed-meshheading:21332939-Receptors, Opioid
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pubmed:year |
2011
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pubmed:articleTitle |
Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months.
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pubmed:affiliation |
School of Pharmacy, St Lucia Campus, The University of Queensland, Brisbane, Queensland, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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