Linked Life Data

21332399

Source:http://linkedlifedata.com/resource/pubmed/id/21332399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-2-21
pubmed:abstractText
This study evaluated the anti-obesity effects of Phellinus baumii extract (PBE) in high-fat diet (HFD)-fed mice. Male 8-week-old C57BL/6 mice were randomly divided into four groups: control, normal chow diet plus vehicle; HFD-control, high-fat plus vehicle; HFD plus orlistat (Xenical(®), Roche, Basel, Switzerland) (50?mg/kg); and HFD plus PBE (500?mg/kg). PBE was administered daily by oral gavage for 12 weeks. Oral administration of PBE (500?mg/kg) significantly reduced body weight gain, hepatic lipid concentrations, and fat accumulation in epididymal adipocytes compared with mice fed HFD alone (P?<?.05). mRNA expression of genes related to triglyceride (TG) synthesis was suppressed in the PBE groups, and fatty acid synthase activity was also significantly inhibited (P?<?.05). Furthermore, we evaluated the effect of PBE on TG absorption and detected marked reduction in TG absorption in Xenical- and PBE-treated mice compared with the control group (P?<?.05). To determine the active compound of PBE, fractionation was conducted, and interfungin A, davallialactone, and hypholomine B were identified as the main compounds. Among the three identified compounds, as a representative compound, davallialactone was also shown to suppress fat accumulation in an in vitro model system. These anti-obesity and hypolipidemic effects appear to be partly mediated by suppressing plasma and hepatic fat accumulation through the inhibition of enzymes associated with hepatic and intestinal lipid absorption and synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1557-7600
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-18
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:21332399-Adipocytes, pubmed-meshheading:21332399-Adipose Tissue, pubmed-meshheading:21332399-Animals, pubmed-meshheading:21332399-Anti-Obesity Agents, pubmed-meshheading:21332399-Basidiomycota, pubmed-meshheading:21332399-Biological Agents, pubmed-meshheading:21332399-Dietary Fats, pubmed-meshheading:21332399-Epididymis, pubmed-meshheading:21332399-Fatty Acid Synthetase Complex, pubmed-meshheading:21332399-Intestinal Absorption, pubmed-meshheading:21332399-Lactones, pubmed-meshheading:21332399-Lipid Metabolism, pubmed-meshheading:21332399-Liver, pubmed-meshheading:21332399-Male, pubmed-meshheading:21332399-Mice, pubmed-meshheading:21332399-Mice, Inbred C57BL, pubmed-meshheading:21332399-Obesity, pubmed-meshheading:21332399-Phytotherapy, pubmed-meshheading:21332399-RNA, Messenger, pubmed-meshheading:21332399-Random Allocation, pubmed-meshheading:21332399-Triglycerides, pubmed-meshheading:21332399-Weight Gain
pubmed:year
2011
pubmed:articleTitle
A Phellinus baumii extract reduces obesity in high-fat diet-fed mice and absorption of triglyceride in lipid-loaded mice.
pubmed:affiliation
Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, Iksan, Jeonbuk, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't