Linked Life Data

21331889

Source:http://linkedlifedata.com/resource/pubmed/id/21331889

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-2-18
pubmed:abstractText
RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed of two distinct homodimeric subunits encoded by UL39 and UL40, respectively. In this study, we applied siRNAs targeting the UL39 and UL40 genes of HSV-1. We showed that synthetic siRNA silenced effectively and specifically UL39 and UL40 mRNA expression and inhibited HSV-1 replication. Our work offers new possibilities for RNAi as a genetic tool for inhibition of HSV-1 replication.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1995-820X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Effect of siRNAs on HSV-1 plaque formation and relative expression levels of RR mRNA.
pubmed:affiliation
Biomedicine research and development center of Jinan University, Guangdong, Guangzhou 510632, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't