Linked Life Data

21331798

Source:http://linkedlifedata.com/resource/pubmed/id/21331798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-3-28
pubmed:abstractText
The results of the CAPRISA 004 and iPrEx HIV prevention studies have demonstrated that topical or systemic use of antiretroviral agents can significantly reduce the risk of HIV acquisition associated with unprotected vaginal or anal sexual intercourse. However, the effect size in these studies was relatively modest and product adherence was generally poor. These observations suggest the need for new approaches to HIV prevention, especially for high risk MSM. Rates of lubricant use are high in MSM practicing receptive anal sex. Consequently, the development of an antiretroviral rectal microbicide gel may provide a safe and effective means of preventing HIV infection with an intervention that is likely to have high acceptability among the target population. The purpose of this article is to describe the challenges and progress in the development of rectal microbicides for HIV prevention.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1573-3254
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S66-71
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Rectal microbicides: can we make them and will people use them?
pubmed:affiliation
Department of Medicine, Division of Gastroenterology, Haepatology, and Nutrition, University of Pittsburgh School of Medicine, 204 Craft Ave., Room B505, Pittsburgh, PA 15213, USA. imcgowan@pitt.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural