Linked Life Data

21331197

Source:http://linkedlifedata.com/resource/pubmed/id/21331197

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-2-18
pubmed:abstractText
A new simple, sensitive, precise, and accurate high-performance liquid chromatography (HPLC) method of analysis for artemether both as a bulk drug and in capsule formulations was developed and validated. The method employed mobile phase acetonitrile (ACN) and buffer in the ratio 65:35 of pH 6.5 adjusted with tryethylamine. The linear regression analysis data for the calibration plots showed good linear relationship with r(2) = 0.9996 in the concentration range 250-750 ?g/ml. The mean value slope and intercept were 9355.5 and -93.5, respectively. The method was validated for precision, accuracy, and recovery studies. Limit of detection (LOD) and Limit of quantitation (LOQ) for artemether were found to be 21.83-750 ?g/ml, respectively. The method has been successfully applied in the analysis of marketed capsule formulations. The presented method was found to be reliable to separate all the degradents from all the stress conditions with resolution of more than 1.5 showing that it is a stability indicating method.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jan
pubmed:issn
0975-1505
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-84
pubmed:dateRevised
2011-7-25
pubmed:year
2010
pubmed:articleTitle
Stability indicating high-performance liquid chromatography method for the estimation of artemether in capsule dosage forms.
pubmed:affiliation
Department of Pharm. Sciences, B.R. Nahata College of Pharmacy, Mhow-Neemuch Road, Mandsaur (M.P) - 458 001, India.
pubmed:publicationType
Journal Article