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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-2-18
pubmed:abstractText
The present study was undertaken to study the role of PAR-2 receptor activation in pathophysiology of intestinal inflammation. Inflammatory bowel disease was induced in Wistar albino rats by intrarectal administration of 2, 4, 6 trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on 1(st) day only). Trypsin (500 ?g/kg, 1 mg/kg, 5 mg/kg, intrarectal) was given from the same day up to 20 days. Various physical parameters including body weight, food and water intake were measured on 1(st) and 20(th) days. At end of the experiment, colon weight and various histopathological indexes were assessed. The colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD) and % mast cell protection in mesentery were also measured. Trypsin at higher dose (5 mg/kg) showed the higher level of oxidative enzymes and lower level of protective enzymes as compared to the animals treated with only TNBS. Trypsin treatment produced significantly more mast cell degranulation. Finally in the histopathology, there was increased in severity of the disease in trypsin-treated animals. The role of PAR-2 (protease activated receptor-2) receptor in gut is pro-inflammatory and thus appears as a new potential therapeutic target for inflammatory bowel disease treatments.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-10455252, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-10528212, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-11356985, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-11718529, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-13219275, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-14606091, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-15302898, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-16260582, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-17940831, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-18460552, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-1977567, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-19861848, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-3874706, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-4165954, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-4262347, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-8564891, http://linkedlifedata.com/resource/pubmed/commentcorrection/21331192-8638193
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jan
pubmed:issn
0975-1505
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
54-8
pubmed:dateRevised
2011-7-25
pubmed:year
2010
pubmed:articleTitle
Investigation of Possible Role of the PAR-2 Receptor in Intestinal Inflammation.
pubmed:affiliation
Department of Pharmacology, Shree Sarvajanik Pharmacy College, Mahesana, India.
pubmed:publicationType
Journal Article