Linked Life Data

2133107

Source:http://linkedlifedata.com/resource/pubmed/id/2133107

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-3-2
pubmed:abstractText
The nuclear proto-oncogenes, c-fos and c-jun, are induced in response to a diverse array of extracellular stimuli. Their protein products, Fos and Jun, form a heterodimeric complex that interacts with the DNA regulatory element known as the AP-1 binding site. Protein dimerization occurs via a parallel interaction of leucine zipper domains and is required for DNA binding. In addition to the leucine zipper, DNA binding requires two clusters of basic amino acids adjacent to the leucine zipper domains of both Fos and Jun. The leucine zipper and DNA-binding regions are highly conserved among the c-fos and c-jun families of related inducible genes. Thus, multiple protein complexes can be formed that may interact with AP-1 binding sites in numerous genes to affect gene expression in response to environmental signals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1044-579X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:geneSymbol
c-fos, c-jun, fra 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-26
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Encounters with Fos and Jun on the road to AP-1.
pubmed:affiliation
Department of Molecular Oncology & Virology, Roche Institute of Molecular Biology, Nutley, NJ 07110.
pubmed:publicationType
Journal Article, Review