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rdf:type |
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lifeskim:mentions |
umls-concept:C0017921,
umls-concept:C0028040,
umls-concept:C0035322,
umls-concept:C0078058,
umls-concept:C0242383,
umls-concept:C0337664,
umls-concept:C0441712,
umls-concept:C0442805,
umls-concept:C0456603,
umls-concept:C1256770,
umls-concept:C1412379,
umls-concept:C1418450
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pubmed:issue |
6
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pubmed:dateCreated |
2011-6-2
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pubmed:abstractText |
Cigarette smoking is the strongest environmental risk factor for wet age-related macular degeneration (AMD). Inappropriate expression of proangiogenic vascular endothelial growth factor (VEGF) and antiangiogenic pigment epithelium derived factor (PEDF) may cause choroidal neovascularization (CNV), a key event in wet AMD, resulting in vision loss. Nicotine (NT), a potent angiogenic agent abundant in second-hand smoke, may play a major role in the pathogenesis of wet AMD. The purpose of this study was to evaluate the expression of nicotinic acetylcholine receptors (nAchR) in retinal pigment epithelium (RPE) and determine the effects of NT on RPE-derived VEGF and PEDF expression in the context of passive smoking.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hexamethonium,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/Serpins,
http://linkedlifedata.com/resource/pubmed/chemical/Tobacco Smoke Pollution,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/pigment epithelium-derived factor
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3842-53
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading |
pubmed-meshheading:21330654-Animals,
pubmed-meshheading:21330654-Blotting, Western,
pubmed-meshheading:21330654-Cell Death,
pubmed-meshheading:21330654-Cell Proliferation,
pubmed-meshheading:21330654-Cells, Cultured,
pubmed-meshheading:21330654-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21330654-Eye Proteins,
pubmed-meshheading:21330654-Hexamethonium,
pubmed-meshheading:21330654-Humans,
pubmed-meshheading:21330654-Male,
pubmed-meshheading:21330654-Nerve Growth Factors,
pubmed-meshheading:21330654-Nicotine,
pubmed-meshheading:21330654-Nicotinic Antagonists,
pubmed-meshheading:21330654-Rats,
pubmed-meshheading:21330654-Rats, Sprague-Dawley,
pubmed-meshheading:21330654-Receptors, Nicotinic,
pubmed-meshheading:21330654-Retinal Pigment Epithelium,
pubmed-meshheading:21330654-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21330654-Serpins,
pubmed-meshheading:21330654-Tobacco Smoke Pollution,
pubmed-meshheading:21330654-Vascular Endothelial Growth Factor A,
pubmed-meshheading:21330654-Wet Macular Degeneration
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pubmed:year |
2011
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pubmed:articleTitle |
Nicotine increases the VEGF/PEDF ratio in retinal pigment epithelium: a possible mechanism for CNV in passive smokers with AMD.
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pubmed:affiliation |
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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