|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2011-3-30
|
|
pubmed:abstractText |
The indirect recruitment (tethering) of estrogen receptors (ERs) to DNA through other DNA-bound transcription factors (e.g. activator protein 1) is an important component of estrogen-signaling pathways, but our understanding of the mechanisms of ligand-dependent activation in this pathway is limited. Using proteomic, genomic, and gene-specific analyses, we demonstrate that a large repertoire of DNA-binding transcription factors contribute to estrogen signaling through the tethering pathway. In addition, we define a set of endogenous genes for which ER? tethering through activator protein 1 (e.g. c-Fos) and cAMP response element-binding protein family members mediates estrogen responsiveness. Finally, we show that functional interplay between c-Fos and cAMP response element-binding protein 1 contributes to estrogen-dependent regulation through the tethering pathway. Based on our results, we conclude that ER? recruitment in the tethering pathway is dependent on the ligand-induced formation of transcription factor complexes that involves interplay between the transcription factors from different protein families.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1944-9917
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
25
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
564-74
|
|
pubmed:meshHeading |
pubmed-meshheading:21330404-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:21330404-DNA-Binding Proteins,
pubmed-meshheading:21330404-Estrogen Receptor alpha,
pubmed-meshheading:21330404-Gene Expression Regulation,
pubmed-meshheading:21330404-HeLa Cells,
pubmed-meshheading:21330404-Humans,
pubmed-meshheading:21330404-Mass Spectrometry,
pubmed-meshheading:21330404-Polymerase Chain Reaction,
pubmed-meshheading:21330404-Protein Array Analysis,
pubmed-meshheading:21330404-Proteomics,
pubmed-meshheading:21330404-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:21330404-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:21330404-Signal Transduction,
pubmed-meshheading:21330404-Transcription Factor AP-1
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway.
|
|
pubmed:affiliation |
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
