Linked Life Data

2132822

Source:http://linkedlifedata.com/resource/pubmed/id/2132822

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-2-18
pubmed:abstractText
In the developing brain, neurons are derived from multipotential precursor cells in a precise sequence, where the time when a neuron becomes postmitotic is closely linked to the differentiated function of the neuron. Work from our group (1) identifies the Nes+ neuronal precursor state, (2) defines growth factors that regulate the proliferation of Nes+ precursor cells and their differentiation into neurons, and (3) establishes immortal cell lines that may be useful models for the terminal differentiation of Nes+ cells into neurons and astrocytes. These results suggest that the basic technical requirements are now in place to define the signals that control the transition from a precursor cell to a postmitotic neuron in the mammalian CNS. Control of this terminal differentiation is a key step in generating the large numbers and types of cells in the CNS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0091-7451
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-301
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Mechanisms regulating cell number and type in the mammalian central nervous system.
pubmed:affiliation
Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge 02139.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't