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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2 R172 in glioma patients. Genetic evidence indicates that these mutations share a common gain of function, but it is unclear whether the shared function is dominant negative activity, neomorphic production of (R)-2-hydroxyglutarate (2HG), or both.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-1329795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-15166110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-16959974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-18772396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-19228619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-19359588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-19378339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-19435942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-19657110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-19935646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-19996293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-20107228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-20127344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-20129244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-20129251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-20142433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-20171147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-20603105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-21130701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21326614-2200929
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e16812
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pubmed:meshHeading |
pubmed-meshheading:21326614-Binding, Competitive,
pubmed-meshheading:21326614-Brain Neoplasms,
pubmed-meshheading:21326614-Cells, Cultured,
pubmed-meshheading:21326614-Down-Regulation,
pubmed-meshheading:21326614-Enzyme Activation,
pubmed-meshheading:21326614-Genes, Dominant,
pubmed-meshheading:21326614-Glioma,
pubmed-meshheading:21326614-Glutarates,
pubmed-meshheading:21326614-Humans,
pubmed-meshheading:21326614-Isocitrate Dehydrogenase,
pubmed-meshheading:21326614-Mutation, Missense
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pubmed:year |
2011
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pubmed:articleTitle |
2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.
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pubmed:affiliation |
The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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