Source:http://linkedlifedata.com/resource/pubmed/id/21325250
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-2-17
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| pubmed:abstractText |
D-dimer is formed during activation of the coagulation system and is commonly assayed in order to diagnose disseminated intravascular coagulation, deep vein thrombosis, and pulmonary embolism. Enzyme-linked immunosorbent assay has been validated as the reference method, but it is a time-consuming procedure. The objective of this study was to evaluate a new immunoturbidimetric, particle-enhanced, Innovance(®) D-dimer immunoassay. A total of 129 plasma samples from apparently healthy individuals and 298 samples from patients were collected for linearity, precision, and correlation studies. Testing the precision of low- and high-controls yielded CV values of 2.08% and 1.76%, respectively. The central 95% non-parametric reference interval estimated from healthy controls was 0.093-0.68 mg/L Fibrinogen Equivalent Units (FEU; median, 0.26 mg/L FEU). Comparison analysis yielded acceptable correlation with the STA Liatest(®) D-dimer assay (R(2) = 0.9471). At a cut-off level of <0.5 mg/L FEU, the sensitivity and specificity indices of the Innovance D-dimer assay were 99.7% and 89.1%, respectively. Thus the Innovance D-dimer method showed acceptable precision and linearity, and the assay results showed acceptable correlation with the STA Liatest D-dimer method. The Innovance method was relatively unaffected by potential interfering substances such as bilirubin and hemoglobin. In conclusion, the Innovance D-dimer assay is suitable for monitoring D-dimer concentrations in various clinical conditions and should be useful in clinical laboratories.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1550-8080
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
41
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
20-4
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| pubmed:meshHeading |
pubmed-meshheading:21325250-Adolescent,
pubmed-meshheading:21325250-Adult,
pubmed-meshheading:21325250-Aged,
pubmed-meshheading:21325250-Aged, 80 and over,
pubmed-meshheading:21325250-Bilirubin,
pubmed-meshheading:21325250-Blood Coagulation Tests,
pubmed-meshheading:21325250-Blotting, Western,
pubmed-meshheading:21325250-Child,
pubmed-meshheading:21325250-Child, Preschool,
pubmed-meshheading:21325250-Female,
pubmed-meshheading:21325250-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:21325250-Hemoglobins,
pubmed-meshheading:21325250-Humans,
pubmed-meshheading:21325250-Immunoassay,
pubmed-meshheading:21325250-Infant,
pubmed-meshheading:21325250-Infant, Newborn,
pubmed-meshheading:21325250-Male,
pubmed-meshheading:21325250-Middle Aged,
pubmed-meshheading:21325250-Young Adult
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Evaluation of performance including influence by interfering substances of the Innovance D-dimer assay on the Sysmex coagulation analyzer.
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| pubmed:affiliation |
Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, Korea.
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| pubmed:publicationType |
Journal Article,
Evaluation Studies
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