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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-3-22
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pubmed:abstractText |
Search for new substances with antiproliferative activity towards melanoma cells is important since malignant melanoma is notoriously resistant to conventional chemotherapy. Benzo[c]phenanthridine alkaloids (BAs) are natural products with significant anti-proliferative activities, therefore they are considered as agents promising for cancer therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-569X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22-35
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pubmed:meshHeading |
pubmed-meshheading:21324654-Alkaloids,
pubmed-meshheading:21324654-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:21324654-Apoptosis,
pubmed-meshheading:21324654-Benzophenanthridines,
pubmed-meshheading:21324654-Caspases,
pubmed-meshheading:21324654-Cell Proliferation,
pubmed-meshheading:21324654-Cell Survival,
pubmed-meshheading:21324654-DNA,
pubmed-meshheading:21324654-DNA Damage,
pubmed-meshheading:21324654-Genes, p53,
pubmed-meshheading:21324654-Humans,
pubmed-meshheading:21324654-Melanoma,
pubmed-meshheading:21324654-Models, Biological,
pubmed-meshheading:21324654-Models, Chemical,
pubmed-meshheading:21324654-Skin Neoplasms,
pubmed-meshheading:21324654-Tumor Suppressor Protein p53
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pubmed:year |
2011
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pubmed:articleTitle |
Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status.
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pubmed:affiliation |
Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A16, 62500 Brno, Czech Republic.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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