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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-5-16
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pubmed:abstractText |
Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling cascades play important roles in the transmission of signals involved in apoptosis. Importantly, components of these pathways are aberrantly expressed in human cancer. However, there is limited data linking clinical outcomes with the aberrant expression of this pathway. The present study analyzed the prognostic values of pan-Ras, Raf-1, phosphorylated MEK1 (pMEK1) and phosphorylated ERK1/2 (pERK1/2) in hepatocellular carcinoma (HCC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1532-2157
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-20
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pubmed:meshHeading |
pubmed-meshheading:21324414-Adult,
pubmed-meshheading:21324414-Aged,
pubmed-meshheading:21324414-Carcinoma, Hepatocellular,
pubmed-meshheading:21324414-Disease-Free Survival,
pubmed-meshheading:21324414-Female,
pubmed-meshheading:21324414-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:21324414-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21324414-Humans,
pubmed-meshheading:21324414-Immunohistochemistry,
pubmed-meshheading:21324414-Kaplan-Meier Estimate,
pubmed-meshheading:21324414-Liver Neoplasms,
pubmed-meshheading:21324414-MAP Kinase Kinase 1,
pubmed-meshheading:21324414-Male,
pubmed-meshheading:21324414-Middle Aged,
pubmed-meshheading:21324414-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:21324414-Neoplasm Recurrence, Local,
pubmed-meshheading:21324414-Predictive Value of Tests,
pubmed-meshheading:21324414-Prognosis,
pubmed-meshheading:21324414-Proportional Hazards Models,
pubmed-meshheading:21324414-Risk Factors,
pubmed-meshheading:21324414-Signal Transduction,
pubmed-meshheading:21324414-Tumor Markers, Biological,
pubmed-meshheading:21324414-raf Kinases,
pubmed-meshheading:21324414-ras Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Expression and prognostic role of pan-Ras, Raf-1, pMEK1 and pERK1/2 in patients with hepatocellular carcinoma.
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pubmed:affiliation |
Department of Medical Oncology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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