Linked Life Data

2132406

Source:http://linkedlifedata.com/resource/pubmed/id/2132406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-1-14
pubmed:abstractText
The effects of changes in the content of dietary carbohydrate, protein and fat on glucose metabolism and insulin secretion were examined in normal male rats. The animals were fed for 10 days with three types of diet: (a) standard diet, (b) glucose diet and (c) high fat/protein diet. The weight of the rats fed with the glucose diet decreased when compared to the standard diet fed rats. The glucose diet decreased insulin secretion in response to glucose in vivo and in vitro and slightly improved glucose tolerance. The hepatic glycogen content was approximately three times higher in animals fed with the glucose diet than in the control group. When compared to the standard diet, the high fat/protein diet induced an increase of the weight gain. This type of diet caused an increase of the fasting plasma glucose, a decrease of hepatic glycogen and a marked glucose intolerance to an intravenous load as demonstrated by lower rates of glucose disappearance. Plasma insulin levels were increased both in basal and glucose stimulated states. These results indicate that the glucose diet leads to an enhanced insulin sensitivity of the target tissues. By contrast, the high fat/protein diet induces an obesity-like state and an in vivo insulin resistance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0265-5985
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-83
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of high-carbohydrate or high-fat diet on carbohydrate metabolism and insulin secretion in the normal rat.
pubmed:affiliation
Department of Medical Biochemistry, School of Medicine, University of Sevilla, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't