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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-6-9
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pubmed:abstractText |
Patients with diabetes mellitus require pharmacotherapy with numerous medications. However, the effect of diabetes on drug biotransformation is not well understood. Our goal was to investigate the effect of diabetes on liver cytochrome P450 3As, the most abundant phase I drug-metabolizing enzymes in humans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
937-47
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pubmed:meshHeading |
pubmed-meshheading:21323901-Blotting, Western,
pubmed-meshheading:21323901-Case-Control Studies,
pubmed-meshheading:21323901-Chromatography, High Pressure Liquid,
pubmed-meshheading:21323901-Cytochrome P-450 CYP3A,
pubmed-meshheading:21323901-Diabetes Mellitus,
pubmed-meshheading:21323901-Female,
pubmed-meshheading:21323901-Genotype,
pubmed-meshheading:21323901-Humans,
pubmed-meshheading:21323901-Male,
pubmed-meshheading:21323901-Microsomes, Liver,
pubmed-meshheading:21323901-Middle Aged,
pubmed-meshheading:21323901-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21323901-Tandem Mass Spectrometry
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pubmed:year |
2011
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pubmed:articleTitle |
Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.
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pubmed:affiliation |
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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