Source:http://linkedlifedata.com/resource/pubmed/id/21322986
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Transitional-cell carcinoma of the bladder has been induced by chronic oral administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) in C3H/He mice, and successfully transplanted in syngeneic animals. Evaluation of the effectiveness of several chemotherapeutic agents on this tumor indicated that cyclophosphamide and cis-diammine dichloroplatinum (CACP) significantly inhibited tumor growth and prolonged the median survival time of tumor-bearing animals. When administered before formation of palpable tumors, cyclophosphamide completely prevented growth of the implants in 100 per cent of animals; when administered after the growth of larger, palpable tumors, cyclophosphamide inhibited tumor growth in all animals and produced a "cure" in 45 per cent. Combination chemotherapy with cyclophosphamide and CACP was more effective than either drug used as a single agent. Adriamycin, dactinomycin, and mitomycin C administered individually exhibited limited activity while 5-fluorouracil, CCNU (1-2 choloroethyl-3-cyclohexyl-1-nitrosourea), BCNU (1,3-bis [2-chloroethyl]-1-nitrosourea), methrotrexate, and hydroxyurea were ineffective against this tumor. The consistent growth pattern, the histologic similarity to bladder cancer in human beings, and the successful propagation in syngeneic animals, make the FANFT-induced tumor a suitable model for chemotherapy of bladder carcinoma in human beings.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0090-4295
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-8
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pubmed:meshHeading | |
pubmed:year |
1974
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pubmed:articleTitle |
Chemotherapy of experimental transitional-cell carcinoma.
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pubmed:affiliation |
Department of Surgery, Division of Urology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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