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rdf:type |
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lifeskim:mentions |
umls-concept:C0006826,
umls-concept:C0033578,
umls-concept:C0087071,
umls-concept:C0431085,
umls-concept:C0681205,
umls-concept:C0870134,
umls-concept:C0871161,
umls-concept:C1148756,
umls-concept:C1550555,
umls-concept:C1637379,
umls-concept:C2346501
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pubmed:issue |
13
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pubmed:dateCreated |
2011-8-10
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pubmed:abstractText |
Cancer progenitor cells (CPCs) have been postulated to promote treatment resistance and disease progression in prostate and other malignancies. We investigated whether the enzyme telomerase, which is active in cancer cells and in normal stem cells, plays an important role in CPC which can be exploited to neutralize these cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-0045
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1390-400
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pubmed:meshHeading |
pubmed-meshheading:21321978-Animals,
pubmed-meshheading:21321978-Antigens, CD44,
pubmed-meshheading:21321978-Humans,
pubmed-meshheading:21321978-Integrin alpha2beta1,
pubmed-meshheading:21321978-Male,
pubmed-meshheading:21321978-Mice,
pubmed-meshheading:21321978-Neoplastic Stem Cells,
pubmed-meshheading:21321978-Prostatic Neoplasms,
pubmed-meshheading:21321978-RNA, Small Interfering,
pubmed-meshheading:21321978-Telomerase,
pubmed-meshheading:21321978-Xenograft Model Antitumor Assays
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pubmed:year |
2011
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pubmed:articleTitle |
Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interference.
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pubmed:affiliation |
Division of Medical Oncology, Department of Internal Medicine, University of Southern California Keck School of Medicine and Norris Comprehensive Cancer Center, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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