Source:http://linkedlifedata.com/resource/pubmed/id/21320571
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-3-25
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| pubmed:abstractText |
Neurotrophic factors support the survival of dopaminergic neurons. The cerebral dopamine neurotrophic factor (CDNF) is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). To investigate whether rare or common variants in CDNF are associated with Parkinson disease (PD), we performed mutation analysis of CDNF and a genetic association study between CDNF polymorphisms and PD. We screened 110 early-onset Parkinson disease (EOPD) patients for CDNF mutations. Allelic and genotype frequencies of 3 CDNF single nucleotide polymorphisms (SNPs) (rs1901650, rs7094179, and rs11259365) were compared in 215 PD patients and age- and sex-matched controls. We failed to identify any mutations in CDNF among the EOPD patient sample population. We observed a trend towards increased risk for PD in patients carrying the C allele of SNP rs7094179 (odds ratio (OR)=1.27, 95% confidence interval (CI) 0.96-1.67). Patients carrying the C allele were susceptible to PD in both dominant (CC+CA vs. AA; OR=7.20, 95% CI 0.88-59.1) and recessive (CA+AA vs. CC; OR=0.64, 95% CI 0.41-0.99) models. Genotype and allele frequencies of SNPs rs1901650 and rs11259365 did not differ between PD patients and controls. Our study suggests that the C allele of an intronic CDNF SNP (rs7094179) might be an allele for susceptibility to PD. Further studies with larger sample size are required to confirm our results.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1872-7972
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
493
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
97-101
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| pubmed:meshHeading |
pubmed-meshheading:21320571-Adolescent,
pubmed-meshheading:21320571-Adult,
pubmed-meshheading:21320571-Aged,
pubmed-meshheading:21320571-Aged, 80 and over,
pubmed-meshheading:21320571-Case-Control Studies,
pubmed-meshheading:21320571-Cytosine Nucleotides,
pubmed-meshheading:21320571-Female,
pubmed-meshheading:21320571-Gene Frequency,
pubmed-meshheading:21320571-Genetic Predisposition to Disease,
pubmed-meshheading:21320571-Genome-Wide Association Study,
pubmed-meshheading:21320571-Heterozygote Detection,
pubmed-meshheading:21320571-Humans,
pubmed-meshheading:21320571-Male,
pubmed-meshheading:21320571-Middle Aged,
pubmed-meshheading:21320571-Mutation,
pubmed-meshheading:21320571-Nerve Growth Factors,
pubmed-meshheading:21320571-Parkinson Disease,
pubmed-meshheading:21320571-Polymorphism, Single Nucleotide,
pubmed-meshheading:21320571-Risk Factors,
pubmed-meshheading:21320571-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease.
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| pubmed:affiliation |
ILSONG Institute of Life Science, Hallym University, Rm 607, ILSONG Bldg, 1605-4 Gwanyang-dong, Dongan-gu, Anyang, Gyonggi-do 431-060, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|