Linked Life Data

21318596

Source:http://linkedlifedata.com/resource/pubmed/id/21318596

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-7-18
pubmed:abstractText
Infertility is an emotionally charged problem, and it is a condition of increasing incidence. In addition, in 40% to 60% of all infertile couples, it was the male who had a problem that led to infertility. Among the male fertility problems, non-obstructive azoospermia (NOA) (caused by testis failure or impaired spermatogenesis) is the most prevalent. Despite enormous clinical and experimental efforts, treatment of this disorder--assistant reproduction technique (ART) with donor spermatozoa remains controversial. We present the hypothesis that induced pluripotent stem (iPS) cell derived spermatozoa can be a potential source for male gametes for patients with NOA; we support this with the following three evidence: the first is the generation of viable, live-born, fertile mature organism from iPS cells; the second is the successful induced differentiation of male gametes from pluripotent cells in vitro; and the last is the wide use of intracytoplasmic sperm injection (ICSI) in human assisted reproduction. If the hiPS derived spermatozoa prove practical in the generation offspring with ICSI, this method might be able to grant a new chance for NOA patients to have their genetic children with fewer emotional, ethical and legislative problems. To ensure the safety of the technology itself and the production of healthy offspring, further investigations are needed. We also suggest several laboratory and clinical approaches for testing our hypothesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1558-6804
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
714-21
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Application of iPS in assisted reproductive technology: sperm from somatic cells?
pubmed:affiliation
Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, China. liushanrong@hotmail.com
pubmed:publicationType
Journal Article