Linked Life Data

21318573

Source:http://linkedlifedata.com/resource/pubmed/id/21318573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-7-11
pubmed:abstractText
Extramedullary relapses after allogeneic stem cell transplantation, especially within the central nervous system (CNS), are not only difficult to treat but also associated with poor outcome. Although the graft-versus-leukemia (GvL) effect is nowadays accepted and well documented, it remains controversial whether one can make use of GvL effects in immunological-restricted areas ("sanctuary sites") like the central nervous system. Here, we present data of three hematological patients suffering from isolated CNS relapse of CML or AML after allogeneic stem cell transplantation. Patients received in addition to chemotherapy intrathecal infusions of donor lymphocytes by CD14 depletion of peripheral blood mononuclear cells from the correspondent allogeneic donor. Referring to an observation period of maximum 17 months no immediate or delayed side effects could be detected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1432-0584
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
911-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Intrathecal application of donor lymphocytes in leukemic meningeosis after allogeneic stem cell transplantation.
pubmed:affiliation
Campus Benjamin Franklin, Department of Hematology and Oncology, Charité, University Hospital Berlin, Berlin, Germany.
pubmed:publicationType
Journal Article, Case Reports