Linked Life Data

21317915

Source:http://linkedlifedata.com/resource/pubmed/id/21317915

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-3-8
pubmed:abstractText
Understanding the defense mechanisms of the host of an organism is important for infection control. In previous studies, we demonstrated that interferon-? (IFN-?), but not IL-12, was produced by human peripheral blood mononuclear cells infected with varicella-zoster virus (VZV). Here, we investigated what kind of cell(s) and which signal molecule(s) are involved in IFN-? production. Using cell isolation and ELISA, we found that plasmacytoid dendritic cells (pDCs) were responsible for IFN-? production during VZV infection. We also found that Toll-like receptor 9 (TLR9) was involved in VZV-induced IFN-? production because inhibitory CpG oligodeoxynucleotide inhibited IFN-? production. UV-inactivated VZV-induced IFN-? production was lower than that of active VZV, indicating another TLR9-independent pathway. Further studies demonstrated that double-stranded RNA-dependent protein kinase, but not DNA-dependent protein kinase was involved in VZV-induced IFN-? production. Together, these results suggest that pDCs play an important role in IFN-? production during VZV infection through TLR9-dependent and -independent pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
2042-0226
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
IFN-? production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and -independent pathways.
pubmed:affiliation
Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't