Source:http://linkedlifedata.com/resource/pubmed/id/21317880
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2011-6-1
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| pubmed:abstractText |
Gene expression profiling is an important tool to evaluate genetic heterogeneity in carcinomas and is useful to develop expression-based classifications for many types of cancer, as well as markers of disease outcome. In this study, we have investigated the expression profile of 22 genes involved in the PI3K-AKT pathway in 26 high-grade ovarian carcinomas (19 serous and 7 clear cell carcinomas). Unsupervised hierarchical clustering divided high-grade ovarian carcinomas into three groups. Although all clear cell carcinomas clustered in one group, high-grade serous carcinomas were segregated into two separate groups with different prognosis (P=0.05). High expression of CASP3, XIAP (X-linked inhibitor of apoptosis) , NFKB1, FAS, and GSK3B mRNAs identified high-grade serous carcinomas with better prognosis. In multivariate analysis, these cluster groups were of prognostic significance independent of age, tumor size, and tumor stage (P=0.008). To validate the mRNA expression data, we studied the immunohistochemical expression of caspase-3 and XIAP on a tissue microarray. Immunoreaction for caspase-3 was concordant with the results obtained by mRNA expression analysis (Spearman r=0.762, P=0.000). Caspase-3 was exclusively expressed by the macrophages. Furthermore, co-expression of caspase-3 and XIAP identified high-grade serous carcinomas with different prognosis (P=0.03). Our results suggest that there are different biological subtypes of high-grade serous carcinomas.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/X-Linked Inhibitor of Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/XIAP protein, human
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1530-0285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
24
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
846-54
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| pubmed:meshHeading |
pubmed-meshheading:21317880-Adult,
pubmed-meshheading:21317880-Aged,
pubmed-meshheading:21317880-Aged, 80 and over,
pubmed-meshheading:21317880-Caspase 3,
pubmed-meshheading:21317880-Cystadenocarcinoma, Serous,
pubmed-meshheading:21317880-Female,
pubmed-meshheading:21317880-Gene Expression Profiling,
pubmed-meshheading:21317880-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21317880-Humans,
pubmed-meshheading:21317880-Kaplan-Meier Estimate,
pubmed-meshheading:21317880-Middle Aged,
pubmed-meshheading:21317880-Neoplasm Staging,
pubmed-meshheading:21317880-Ovarian Neoplasms,
pubmed-meshheading:21317880-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:21317880-Prognosis,
pubmed-meshheading:21317880-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21317880-Survival Rate,
pubmed-meshheading:21317880-Tumor Markers, Biological,
pubmed-meshheading:21317880-X-Linked Inhibitor of Apoptosis Protein
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| pubmed:year |
2011
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| pubmed:articleTitle |
Gene expression analysis identifies two groups of ovarian high-grade serous carcinomas with different prognosis.
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| pubmed:affiliation |
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IBB Sant Pau), Autonomous University of Barcelona, Barcelona, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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