Linked Life Data

2131737

Source:http://linkedlifedata.com/resource/pubmed/id/2131737

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-11-27
pubmed:abstractText
Two experiments were made showing that opioid involvement coincides with the magnitude of stress-induced analgesia. In Experiment I rats subjected to cold water swims were screened for jump threshold levels on electrified grid and divided into high, medium and low threshold responders' groups. Later on the three groups were given 90 s forepaw footshock. Tail-flick latencies rose highest in the high threshold, and lowest in the low threshold responders. This decrease in nociception was counteracted by naloxone more effectively in high than in medium threshold responders, and not all in low threshold responders. In Experiment II mice selectively bred for high (HA) and low (LA) post-stress analgesia swam at 20 and 2 degrees C. Both stressors were followed by an increase in tail-flick latencies in the order of magnitude HA greater than unselected controls greater than LA line. Naloxone attenuated analgesia after both stressors in the HA line, but was ineffective in LA mice. In unselected controls swimming at 20 degrees C caused naloxone-sensitive, and cold water swims naloxone-resistant analgesia. It is concluded that apart from the kind of stressor, inborn properties of an individual are essential for the development of opioid vs. non-opioid form of post-stress analgesia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1400
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
535-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Correlation between magnitude and opioid mediation of stress-induced analgesia: individual differences and the effect of selective breeding.
pubmed:affiliation
Department of Behavioral Physiology, Institute of Genetics and Animal Breeding, Mroków, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't