Source:http://linkedlifedata.com/resource/pubmed/id/21317245
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2011-3-28
|
| pubmed:abstractText |
The incidence of osteonecrosis of the jaw (ONJ) in the population is low, but specifics are unknown. Potential risk factors include bisphosphonate treatment, steroid treatment, osteoporosis, and head/neck radiation. This Dental Practice-Based Research Network study estimated ONJ incidence and odds ratios from bisphosphonate exposure and other risk factors using a key word search and manual chart reviews of electronic records for adults aged ? 35 yrs enrolled during 1995-2006 in two large health-care organizations. We found 16 ONJ cases among 572,606 cohort members; seven additional cases were identified through dental plan resources. Among 23 cases (0.63 per 100,000 patient years), 20 (87%) had at least one risk factor, and six (26%) had received oral bisphosphonates. Patients with oral bisphosphonates were 15.5 (CI, 6.0-38.7) more likely to have ONJ than non-exposed patients; however, the sparse number of ONJ cases limits firm conclusions and suggests that the absolute risks for ONJ from oral bisphosphonates is low.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1544-0591
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
433-8
|
| pubmed:dateRevised |
2011-8-12
|
| pubmed:meshHeading |
pubmed-meshheading:21317245-Adult,
pubmed-meshheading:21317245-Bone Density Conservation Agents,
pubmed-meshheading:21317245-Cohort Studies,
pubmed-meshheading:21317245-Community-Based Participatory Research,
pubmed-meshheading:21317245-Diphosphonates,
pubmed-meshheading:21317245-Female,
pubmed-meshheading:21317245-Head,
pubmed-meshheading:21317245-Health Maintenance Organizations,
pubmed-meshheading:21317245-Humans,
pubmed-meshheading:21317245-Incidence,
pubmed-meshheading:21317245-Jaw Diseases,
pubmed-meshheading:21317245-Male,
pubmed-meshheading:21317245-Middle Aged,
pubmed-meshheading:21317245-Minnesota,
pubmed-meshheading:21317245-Neck,
pubmed-meshheading:21317245-Neoplasms,
pubmed-meshheading:21317245-Oregon,
pubmed-meshheading:21317245-Osteonecrosis,
pubmed-meshheading:21317245-Osteoporosis,
pubmed-meshheading:21317245-Retrospective Studies,
pubmed-meshheading:21317245-Risk Factors,
pubmed-meshheading:21317245-Steroids,
pubmed-meshheading:21317245-Washington
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
ONJ in two dental practice-based research network regions.
|
| pubmed:affiliation |
Kaiser Permanente Center for Health Research, 3800 N Interstate Ave, Portland, OR 97227, USA. jeffrey.fellows@kpchr.org
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|