Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-3-2
pubmed:abstractText
Amplification of 8p11-12 in human breast cancers is associated with increased proliferation and tumor grade and reduced metastasis-free patient survival. We identified Zeppo1 (zinc finger elbow-related proline domain protein 1) (FLJ14299/ZNF703) within this amplicon as a regulator of cell adhesion, migration, and proliferation in mammary epithelial cells. Overexpression of Zeppo1 reduces cell-cell adhesion and stimulates migration and proliferation. Knockdown of Zeppo1 induces adhesion and lumen formation. Zeppo1 regulates transcription, complexing with Groucho and repressing E-cadherin expression and Wnt and TGF? reporter expression. Zeppo1 promotes expression of metastasis-associated p120-catenin isoform 1 and alters p120-catenin localization upon cell contact with the extracellular matrix. Significantly, Zeppo1 overexpression in a mouse breast cancer model increases lung metastases, while reducing Zeppo1 expression reduces both tumor size and the number of lung metastases. These results indicate that Zeppo1 is a key regulator of breast cancer progression.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-10207085, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-11728306, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-11880358, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-12020799, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-12087177, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-12117809, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-12297042, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-12646922, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-14550789, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-14554243, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-14610055, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-14709556, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15001537, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15042707, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15057284, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15075229, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15077190, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-1540948, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15449319, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15489912, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15647282, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15688013, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15768032, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15861397, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-15897872, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16025097, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16027731, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16107313, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16380503, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16467384, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16636668, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16678101, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-16943426, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17028013, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17030444, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17081971, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17096335, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17110329, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17116694, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17178857, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17194753, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17206277, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17412698, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17452626, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17508028, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-17517963, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-18089785, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-18292778, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-18335499, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-18363555, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-18371425, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-18407999, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-18485877, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-19014486, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-19171890, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-19609305, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-19619488, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-19692590, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-19763914, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-20039268, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-20151151, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-20371349, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-7671815, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-8653709, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-9566976, http://linkedlifedata.com/resource/pubmed/commentcorrection/21317240-9653641
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1549-5477
pubmed:author
More...