Linked Life Data

21316207

Source:http://linkedlifedata.com/resource/pubmed/id/21316207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8-9
pubmed:dateCreated
2011-6-7
pubmed:abstractText
Metabolic syndrome is a cluster of risk factors including insulin resistance and type 2 diabetes and is found to associate partly with chronic stress at work in human. Adiponectin circulates in mammal blood mainly as a low molecular weight (LMW) trimer, hexamer, and a high molecular weight (HMW) multimers. Low circulating levels of adiponectin are related to metabolic syndrome. We have then investigated the influence of immobilization stress on plasma adiponectin concentrations in mice. Relative LMW and HMW adiponectin levels were markedly reduced by immobilization stress (0.66±0.07 and 0.59±0.06 after 102 h, respectively), significantly different from the control values (p<0.01 and 0.05, respectively). ?-Aminobutyric acid (GABA) and ?-oryzanol abundantly contained in germinated brown rice have some physiological functions. We further investigated the effect of GABA, ?-oryzanol, GABA plus ?-oryzanol on adiponectin levels in mice subjected to immobilization stress. GABA and ?-oryzanol significantly increased the relative LMW and HMW adiponectin levels under immobilization stress (1.10±0.11 and 0.99±0.19 after 102 h, respectively, for GABA; 1.08±0.17 and 1.15±0.17 after 102 h, respectively, for ?-oryzanol). Additionally, the co-administration of GABA and ?-oryzanol also increased both relative LMW and HMW adiponectin levels (1.02±0.07 and 0.99±0.10 after 102 h, respectively) and was effective in an earlier phase from 30 to 54 h. The results indicate that the co-administration of GABA and ?-oryzanol might be effective in preventing stress-induced hypoadiponectinemia in mice and be also a promising tool for improving metabolic syndrome aggravated by chronic stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1618-095X
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier GmbH. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-60
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Oral administration of ?-aminobutyric acid and ?-oryzanol prevents stress-induced hypoadiponectinemia.
pubmed:affiliation
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't