|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0021853,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0038250,
umls-concept:C0221908,
umls-concept:C0949879,
umls-concept:C1257825,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1551591,
umls-concept:C1556066,
umls-concept:C1619636
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2011-4-25
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|
pubmed:abstractText |
Elys is a conserved protein that directs nuclear pore complex (NPC) assembly in mammalian cell lines and developing worms and zebrafish. Related studies in these systems indicate a role for Elys in DNA replication and repair. Intestinal epithelial progenitors of zebrafish elys mutants undergo apoptosis early in development. However, it is not known whether loss of Elys has a similar effect in the mammalian intestine or whether the NPC and DNA repair defects each contribute to the overall phenotype.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1528-0012
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pubmed:author |
|
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1547-55.e10
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pubmed:meshHeading |
pubmed-meshheading:21315719-Alleles,
pubmed-meshheading:21315719-Animals,
pubmed-meshheading:21315719-Apoptosis,
pubmed-meshheading:21315719-Blotting, Southern,
pubmed-meshheading:21315719-Blotting, Western,
pubmed-meshheading:21315719-Cell Line,
pubmed-meshheading:21315719-DNA Repair,
pubmed-meshheading:21315719-Disease Models, Animal,
pubmed-meshheading:21315719-Gene Expression Regulation, Developmental,
pubmed-meshheading:21315719-Genomic Instability,
pubmed-meshheading:21315719-Immunohistochemistry,
pubmed-meshheading:21315719-Intestinal Mucosa,
pubmed-meshheading:21315719-Mice,
pubmed-meshheading:21315719-Microscopy, Electron, Transmission,
pubmed-meshheading:21315719-Nuclear Pore,
pubmed-meshheading:21315719-Phenotype,
pubmed-meshheading:21315719-Polymerase Chain Reaction,
pubmed-meshheading:21315719-RNA,
pubmed-meshheading:21315719-Stem Cells,
pubmed-meshheading:21315719-Transcription Factors,
pubmed-meshheading:21315719-Zebrafish
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pubmed:year |
2011
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pubmed:articleTitle |
The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells.
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pubmed:affiliation |
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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