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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-2-21
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pubmed:abstractText |
The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid butyl amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs were found to have a good anti-tumor activity comparable to cisplatin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1320-4
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pubmed:meshHeading |
pubmed-meshheading:21315586-Animals,
pubmed-meshheading:21315586-Antineoplastic Agents,
pubmed-meshheading:21315586-Cell Line, Tumor,
pubmed-meshheading:21315586-Cell Proliferation,
pubmed-meshheading:21315586-Enzyme Inhibitors,
pubmed-meshheading:21315586-Ethacrynic Acid,
pubmed-meshheading:21315586-Humans,
pubmed-meshheading:21315586-Inhibitory Concentration 50,
pubmed-meshheading:21315586-Mice,
pubmed-meshheading:21315586-Molecular Structure,
pubmed-meshheading:21315586-Neoplasms,
pubmed-meshheading:21315586-Phenylbutyrates,
pubmed-meshheading:21315586-Small Molecule Libraries
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pubmed:year |
2011
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pubmed:articleTitle |
Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries.
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pubmed:affiliation |
Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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