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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7-8
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pubmed:dateCreated |
2011-2-11
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pubmed:abstractText |
Catechol-O-methyltransferase (COMT) may be a risk modifying gene for Nicotine dependence (ND) rather than a direct susceptibility gene for this phenotype. Brain nicotinic cholinergic receptors modulate dopaminergic transmission, and several variants within the neighboring CHRNA5-CHRNA3 genes have been associated with ND. Therefore, it is biologically reasonable to study the interactive contribution of COMT and the CHRNA5 and CHRNA3 genes to ND.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1099-1077
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
536-42
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pubmed:meshHeading |
pubmed-meshheading:21312287-Adult,
pubmed-meshheading:21312287-Catechol O-Methyltransferase,
pubmed-meshheading:21312287-European Continental Ancestry Group,
pubmed-meshheading:21312287-Female,
pubmed-meshheading:21312287-Gene Expression,
pubmed-meshheading:21312287-Genotype,
pubmed-meshheading:21312287-Humans,
pubmed-meshheading:21312287-Nerve Tissue Proteins,
pubmed-meshheading:21312287-Personality,
pubmed-meshheading:21312287-Polymorphism, Single Nucleotide,
pubmed-meshheading:21312287-Receptors, Nicotinic,
pubmed-meshheading:21312287-Risk,
pubmed-meshheading:21312287-Risk Factors,
pubmed-meshheading:21312287-Smoking,
pubmed-meshheading:21312287-Social Environment,
pubmed-meshheading:21312287-Tobacco Use Disorder,
pubmed-meshheading:21312287-Women,
pubmed-meshheading:21312287-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence - role of gene-gene interaction, personality, and environmental factors.
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pubmed:affiliation |
Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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pubmed:publicationType |
Journal Article
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