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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-5-3
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pubmed:abstractText |
Activation of the coagulation cascade leading to generation of thrombin has been documented extensively in various forms of lung injury, including that associated with systemic sclerosis. We previously demonstrated that the direct thrombin inhibitor dabigatran inhibits thrombin-induced profibrotic signaling in lung fibroblasts. This study was undertaken to test whether dabigatran etexilate attenuates lung injury in a murine model of interstitial lung disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1529-0131
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 by the American College of Rheumatology.
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1416-25
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21312187-Administration, Oral,
pubmed-meshheading:21312187-Animals,
pubmed-meshheading:21312187-Antithrombins,
pubmed-meshheading:21312187-Benzimidazoles,
pubmed-meshheading:21312187-Bleomycin,
pubmed-meshheading:21312187-Disease Models, Animal,
pubmed-meshheading:21312187-Female,
pubmed-meshheading:21312187-Lung Diseases, Interstitial,
pubmed-meshheading:21312187-Mice,
pubmed-meshheading:21312187-Mice, Inbred C57BL,
pubmed-meshheading:21312187-Pulmonary Fibrosis,
pubmed-meshheading:21312187-Thrombin,
pubmed-meshheading:21312187-beta-Alanine
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pubmed:year |
2011
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pubmed:articleTitle |
Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease.
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pubmed:affiliation |
Medical University of South Carolina, Charleston, SC, USA. bogatkev@musc.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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