Linked Life Data

21311920

Source:http://linkedlifedata.com/resource/pubmed/id/21311920

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-4-25
pubmed:abstractText
Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (Fc?R)-like proteins that thwart the Fc?-mediated effector functions. Our aim was to determine whether GM allotypes-immunoglobulin ? chain determinants expressed primarily on the Fc segment-modulate this viral strategy through differential binding to the viral Fc?R. Results of our ELISA binding studies show that the mean absorbance values for binding to the HCMV TRL11/IRL11-encoded Fc?R were higher for IgG1 expressing the GM 3 allotype than for those expressing the allelic GM 1,2,17 determinants (p = 0.0005), a finding with potential implications for genetic etiology of HCMV-associated diseases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1432-8798
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
907-10
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
The human cytomegalovirus TRL11/IRL11-encoded Fc?R binds differentially to allelic variants of immunoglobulin G1.
pubmed:affiliation
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, 29425-2230, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural