Linked Life Data

21309613

Source:http://linkedlifedata.com/resource/pubmed/id/21309613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-1
pubmed:abstractText
In this present work, we characterized the proteomes of pancreatic ductal adenocarcinoma (PDAC) cells and normal pancreatic duct cells by mass spectrometry using LTQ-Orbitrap, and identified more than 1200 proteins from each sample. On the basis of spectra count label-free quantification approach, we identified a large number of differentially expressed metabolic enzymes and proteins involved in cytoskeleton, cell adhesion, transport, transcription, translation, and cell proliferation as well. The data demonstrated that metabolic pathways were altered in PDAC, consistent with Warburg effect. Our analysis provides a potentially comprehensive picture of metabolism in PDAC, which may serve as the basis of new diagnostic and treatment of PDAC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1535-3907
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1944-52
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Proteomic analysis of pancreatic ductal adenocarcinoma cells reveals metabolic alterations.
pubmed:affiliation
Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, United States. wzhou@gmu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't