Source:http://linkedlifedata.com/resource/pubmed/id/21306565
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-6-14
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| pubmed:abstractText |
Lamotrigine (LTG) is a commonly used antiepileptic drug. However, the use of LTG is limited because of its cutaneous adverse drug reactions (cADRs) ranging from mild maculopapular eruption (MPE) to severe Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). A strong association between HLA-B*1502 and carbamazepine-induced SJS/TEN has been identified in Chinese and Thai. Although three of seven cases with HLA-B*1502 have been reported in LTG-induced SJS/TEN so far, the relationship between HLA-B*1502 and LTG-induced SJS/TEN needs further investigation. It is also unclear whether there is a specific genetic marker associated with LTG-induced MPE in Chinese. In this study, we genotyped 43 Han Chinese patients treated with LTG (14 cases with LTG-induced cADRs and 29 LTG-tolerant controls), using PCR-SSP for HLA-B*1502 testing and low-resolution genotyping, as well as sequencing for four-digit genotyping. The two cases with SJS were negative for HLA-B*1502, with B1301/1301 and 4601/5610, respectively. Combining the data with previous studies, there was no significant difference in the frequency of subjects with HLA-B*1502 between the LTG-induced SJS/TEN group and the LTG-tolerant group (p?=?0.08, OR 4.23, 95% CI 0.94-18.97). In the MPE group, only one was positive for HLA-B*1502. There was no significant difference in the frequency of a specific HLA-B allele between the MPE group and the LTG-tolerant group either. In this study, no significant association between HLA-B*1502 and LTG-induced SJS or MPE was found. Given the small sample size and only HLA-B locus genotyping, further large-scale studies are required to explore genetic associations with LTG-induced cADRs.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines,
http://linkedlifedata.com/resource/pubmed/chemical/lamotrigine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1742-7843
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2011 The Authors. Basic & Clinical Pharmacology & Toxicology © 2011 Nordic Pharmacological Society.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
109
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
42-6
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| pubmed:meshHeading |
pubmed-meshheading:21306565-Adolescent,
pubmed-meshheading:21306565-Aged,
pubmed-meshheading:21306565-Alleles,
pubmed-meshheading:21306565-Anticonvulsants,
pubmed-meshheading:21306565-Asian Continental Ancestry Group,
pubmed-meshheading:21306565-Base Sequence,
pubmed-meshheading:21306565-Child,
pubmed-meshheading:21306565-Child, Preschool,
pubmed-meshheading:21306565-China,
pubmed-meshheading:21306565-DNA Primers,
pubmed-meshheading:21306565-Drug Eruptions,
pubmed-meshheading:21306565-Female,
pubmed-meshheading:21306565-Gene Frequency,
pubmed-meshheading:21306565-Genotype,
pubmed-meshheading:21306565-HLA-B Antigens,
pubmed-meshheading:21306565-Humans,
pubmed-meshheading:21306565-Male,
pubmed-meshheading:21306565-Molecular Sequence Data,
pubmed-meshheading:21306565-Polymerase Chain Reaction,
pubmed-meshheading:21306565-Triazines,
pubmed-meshheading:21306565-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population.
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| pubmed:affiliation |
Institute of Neuroscience and Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and Ministry of Education of China, Guangzhou, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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