Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2011-8-4
pubmed:abstractText
Esophageal adenocarcinoma is often considered to arise from a clonal stem-like population of cells, which is potentially responsible for its poor prognosis. Transforming growth factor ? (TGF-?) and Notch signaling pathways play important roles in regulating self-renewal of stem cells and cell-fate determination. Both pathways are frequently implicated in gastrointestinal carcinogenesis. However, their contributions to esophageal adenocarcinoma remain unclear.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix..., http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 3 Subunit, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4, http://linkedlifedata.com/resource/pubmed/chemical/HES1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-3, http://linkedlifedata.com/resource/pubmed/chemical/POU5F1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch, http://linkedlifedata.com/resource/pubmed/chemical/Runx3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Serrate proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1097-0142
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 American Cancer Society.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3691-702
pubmed:meshHeading
pubmed-meshheading:21305538-Adenocarcinoma, pubmed-meshheading:21305538-Barrett Esophagus, pubmed-meshheading:21305538-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:21305538-Calcium-Binding Proteins, pubmed-meshheading:21305538-Cell Line, Tumor, pubmed-meshheading:21305538-Cell Proliferation, pubmed-meshheading:21305538-Core Binding Factor Alpha 3 Subunit, pubmed-meshheading:21305538-Cyclin-Dependent Kinase 4, pubmed-meshheading:21305538-Esophageal Neoplasms, pubmed-meshheading:21305538-Esophagus, pubmed-meshheading:21305538-Homeodomain Proteins, pubmed-meshheading:21305538-Humans, pubmed-meshheading:21305538-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:21305538-Membrane Proteins, pubmed-meshheading:21305538-Octamer Transcription Factor-3, pubmed-meshheading:21305538-Receptors, Notch, pubmed-meshheading:21305538-Signal Transduction, pubmed-meshheading:21305538-Transforming Growth Factor beta
pubmed:year
2011
pubmed:articleTitle
Dysfunctional transforming growth factor-? signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma.
pubmed:affiliation
School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural