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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-2-9
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pubmed:abstractText |
The campaign of 2009-2010 Northern Hemisphere seasonal vaccination was concurrent with the 2009 H1N1 pandemic. Using a hemagglutination inhibition (HAI) assay, we evaluated the immunogenicity and cross-reactivity of 2009-2010 inactivated trivalent influenza vaccine (TIV) in US adult and elderly populations. Vaccination of TIV resulted in a robust boost on the antibody response of all subjects to seasonal A/Brisbane/59/2007 (H1N1) and A/Uruguay/716/2007 (H3N2) with over 70% of recipients reaching a seroprotective titer of 40. B/Brisbane/60/2008 was the least immunogenic among the three seasonal vaccine strains with <30% of TIV recipients reaching a seroprotective titer of 40. TIV vaccination also induced a moderate boost on the pandemic specific antibody responses. Twenty-four percent of adults and 36% of elderly reached a seroprotective HAI titer of 40 or more against pandemic A/South Carolina/18/2009 (H1N1) after receiving TIV compared to 4% and 7% at the beginning of vaccination, respectively. In addition, 22% of adults and 34% of elderly showed an increase of 4-fold or more in A/South Carolina/18/2009 specific HAI titers after TIV vaccination. The pandemic specific cross-reactive antibodies strongly correlated with the post-vaccination HAI titers against the seasonal H3N2 vaccine strain in all subjects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-10074505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-15088777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-17064823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-17332179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-18977968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19088005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19465683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19478718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19490957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19745214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19745216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19768400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-19808768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20018365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20026597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20350398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20386731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20431523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20502705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20543954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20723626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-20887210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-21067351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-367490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21304946-7114033
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e16650
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pubmed:meshHeading |
pubmed-meshheading:21304946-Adult,
pubmed-meshheading:21304946-Aged,
pubmed-meshheading:21304946-Antibodies, Viral,
pubmed-meshheading:21304946-Antibody Formation,
pubmed-meshheading:21304946-Cross Reactions,
pubmed-meshheading:21304946-Hemagglutination Tests,
pubmed-meshheading:21304946-Humans,
pubmed-meshheading:21304946-Immunity,
pubmed-meshheading:21304946-Influenza Vaccines,
pubmed-meshheading:21304946-Pandemics,
pubmed-meshheading:21304946-United States
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pubmed:year |
2011
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pubmed:articleTitle |
Immunogenicity and cross-reactivity of 2009-2010 inactivated seasonal influenza vaccine in US adults and elderly.
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pubmed:affiliation |
Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, United States Food and Drug Administration, Bethesda, Maryland, United States of America. Hang.Xie@fda.hhs.gov
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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