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rdf:type |
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lifeskim:mentions |
umls-concept:C0002716,
umls-concept:C0025118,
umls-concept:C0025936,
umls-concept:C0033684,
umls-concept:C0037420,
umls-concept:C0085151,
umls-concept:C0205161,
umls-concept:C0228174,
umls-concept:C0233794,
umls-concept:C0443324,
umls-concept:C1280500,
umls-concept:C1548559,
umls-concept:C1556094,
umls-concept:C2001636
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pubmed:dateCreated |
2011-4-4
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pubmed:abstractText |
The deposition of amyloid ? protein (A?) is a consistent pathological hallmark of Alzheimer's disease (AD) brains. Therefore, inhibition of A? aggregation in the brain is an attractive therapeutic and preventive strategy in the development of disease-modifying drugs for AD. An in vitro study demonstrated that yokukansan (YKS), a traditional Japanese medicine, inhibited A? aggregation in a concentration-dependent manner. An in vivo study demonstrated that YKS and Uncaria hook (UH), a constituent of YKS, prevented the accumulation of cerebral A?. YKS also improved the memory disturbance and abnormal social interaction such as increased aggressive behavior and decreased social behavior in amyloid precursor protein transgenic mice. These results suggest that YKS is likely to be a potent and novel therapeutic agent to prevent and/or treat AD, and that this may be attributed to UH.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-7544
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pubmed:author |
pubmed-author:AraiHH,
pubmed-author:FujiwaraHH,
pubmed-author:IkarashiYY,
pubmed-author:IwasakiKK,
pubmed-author:KaseYY,
pubmed-author:KudoYY,
pubmed-author:SekiguchiKK,
pubmed-author:TabuchiMM,
pubmed-author:TakayamaSS,
pubmed-author:YaegashiNN,
pubmed-author:YamaguchiTT
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pubmed:copyrightInfo |
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-13
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pubmed:meshHeading |
pubmed-meshheading:21303686-Alzheimer Disease,
pubmed-meshheading:21303686-Amyloid beta-Peptides,
pubmed-meshheading:21303686-Amyloid beta-Protein Precursor,
pubmed-meshheading:21303686-Animals,
pubmed-meshheading:21303686-Disease Models, Animal,
pubmed-meshheading:21303686-Drugs, Chinese Herbal,
pubmed-meshheading:21303686-Interpersonal Relations,
pubmed-meshheading:21303686-Japan,
pubmed-meshheading:21303686-Male,
pubmed-meshheading:21303686-Medicine, East Asian Traditional,
pubmed-meshheading:21303686-Memory Disorders,
pubmed-meshheading:21303686-Mice,
pubmed-meshheading:21303686-Mice, Transgenic,
pubmed-meshheading:21303686-Neuroprotective Agents,
pubmed-meshheading:21303686-Phytotherapy,
pubmed-meshheading:21303686-Plant Extracts,
pubmed-meshheading:21303686-Plants, Medicinal
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pubmed:year |
2011
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pubmed:articleTitle |
Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid ? proteins in amyloid precursor protein transgenic mice.
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pubmed:affiliation |
Department of Traditional Asian Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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