Linked Life Data

21303668

Source:http://linkedlifedata.com/resource/pubmed/id/21303668

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-3-28
pubmed:abstractText
Substance P (SP) is a neuropeptide that can modulate inflammatory mediator release through activation of NK(1) receptors (NK(1)R). Some studies have also suggested the involvement of SP in lipopolysaccharide (LPS)-induced fever. However, the precise contribution of this neuropeptide to the pathways activated during fever is unknown. In this study we investigated the effect of a selective NK(1)R antagonist, SR140333B, on the febrile response induced by LPS and cytokines. Our results show that the systemic injection of SR140333B did not modify the fever induced by LPS at a dose that is able to reduce protein extravasation induced by SP in the skin. On the other hand, intracerebroventricular administration of SR140333B significantly reduced the fever induced by peripheral injection of LPS. These data emphasize an important role for SP in the central nervous system during the febrile response to LPS, and are reinforced by the fact that intracerebroventricular injection of SP also induced fever in a dose-dependent manner in captopril-treated rats. Considering that the febrile response can result from the generation of several endogenous pyrogens, among them interleukin (IL)-1? and macrophage inflammatory protein-1? (CCL3/MIP-1?), we also examined the effect of SR140333B on the fever induced by these cytokines which act through prostaglandin-dependent and -independent mechanisms, respectively. Surprisingly, SR140333B did not modify the febrile response to IL-1? or CCL3/MIP-1?. Altogether these data suggest that the central action of SP is essential for LPS-, but not for IL-1?- or CCL3/MIP-1?-induced fever.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1872-6240
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
12
pubmed:volume
1384
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Central substance P NK? receptors are involved in fever induced by LPS but not by IL-1? and CCL3/MIP-1? in rats.
pubmed:affiliation
Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't