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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-25
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pubmed:abstractText |
Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 ?M. Compound 7 showed no cytotoxicity against Vero cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1520-6025
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
208-12
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pubmed:meshHeading |
pubmed-meshheading:21302964-Alkaloids,
pubmed-meshheading:21302964-Animals,
pubmed-meshheading:21302964-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:21302964-Carbazoles,
pubmed-meshheading:21302964-Cercopithecus aethiops,
pubmed-meshheading:21302964-Clausena,
pubmed-meshheading:21302964-Coumarins,
pubmed-meshheading:21302964-Drug Screening Assays, Antitumor,
pubmed-meshheading:21302964-Humans,
pubmed-meshheading:21302964-Inhibitory Concentration 50,
pubmed-meshheading:21302964-KB Cells,
pubmed-meshheading:21302964-Plant Roots
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pubmed:year |
2011
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pubmed:articleTitle |
Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.
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pubmed:affiliation |
Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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