Source:http://linkedlifedata.com/resource/pubmed/id/21302120
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2011-3-24
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pubmed:abstractText |
Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1432-0878
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
344
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-11
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pubmed:meshHeading | |
pubmed:year |
2011
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pubmed:articleTitle |
Global daily dynamics of the pineal transcriptome.
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pubmed:affiliation |
Instituto Tecnológico de Chascomús (Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús), Camino Circunvalación Laguna km 6 cc164, B7130IWA, Chascomús, Argentina.
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pubmed:publicationType |
Journal Article,
Review
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