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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-4-18
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pubmed:abstractText |
Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1538-2443
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-8
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pubmed:dateRevised |
2011-10-5
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pubmed:meshHeading |
pubmed-meshheading:21302026-AIDS Dementia Complex,
pubmed-meshheading:21302026-Algorithms,
pubmed-meshheading:21302026-Atrophy,
pubmed-meshheading:21302026-Automation, Laboratory,
pubmed-meshheading:21302026-Brain,
pubmed-meshheading:21302026-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21302026-Cell Count,
pubmed-meshheading:21302026-Cognition,
pubmed-meshheading:21302026-Cone-Beam Computed Tomography,
pubmed-meshheading:21302026-Female,
pubmed-meshheading:21302026-HIV,
pubmed-meshheading:21302026-HIV Infections,
pubmed-meshheading:21302026-Humans,
pubmed-meshheading:21302026-Magnetic Resonance Imaging,
pubmed-meshheading:21302026-Male,
pubmed-meshheading:21302026-Matrix Metalloproteinase 2,
pubmed-meshheading:21302026-Matrix Metalloproteinase 7,
pubmed-meshheading:21302026-Middle Aged,
pubmed-meshheading:21302026-Viral Load
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pubmed:year |
2011
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pubmed:articleTitle |
Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.
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pubmed:affiliation |
Department of Radiology, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL 60611-2927, USA. ann-ragin@northwestern.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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