Linked Life Data

21301625

Source:http://linkedlifedata.com/resource/pubmed/id/21301625

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2011-2-8
pubmed:abstractText
Biomarkers are gaining increasing interest to predict risk but also to aid in diagnostics. Tissue-specific biomarkers are of utmost importance to detect diseases of respective organs. As of yet there are no atrium-specific biomarkers for risk stratification of atrial disease, such as atrial fibrillation. Bioinformatics such as mRNA microarrays can help to detect tissue-enriched and possibly tissue-specific expressed genes that can be targets for biomarkers. We describe an approach to identify genes preferably expressed in atrial cardiomyocytes compared with ventricular cardiomyocytes by RNA microarray and confirmed by quantitative real-time polymerase chain reaction. By this approach we identified several atrium-enriched genes but also ventricle-enriched genes. As expected atrial natriuretic peptide (ANP) mRNA showed higher expression in atrial cardiomyocytes while with adrenergic stimulation expression was almost as high in ventricular as in atrial cells. Brain-type natriuretic peptide (BNP), however, was not different between atrial and ventricular cells giving a possible explanation for increased levels of NT-proBNP in atrial fibrillation patients. Interesting identified candidates are serpine1 and ltbp2 as atrium-enriched genes whereas alpha-adrenergic receptor subtype 1b and S100A1 expression was significantly higher in ventricular cells. The identified genes need to be confirmed in human tissue and might ultimately be tested as potential biomarkers for atrial stress. (Neth Heart J 2010;18:610-4.).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-12818573, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-15466629, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-16798760, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-17909105, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-18086696, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-18347210, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-18356205, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-18480207, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-18854540, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-19228263, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-19546186, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-19841297, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-20185794, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-20495015, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-20626406, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-20802247, http://linkedlifedata.com/resource/pubmed/commentcorrection/21301625-8951302
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Dec
pubmed:issn
1876-6250
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
610-4
pubmed:dateRevised
2011-7-25
pubmed:year
2010
pubmed:articleTitle
Cardiac gene expression profiling - the quest for an atrium-specific biomarker.
pubmed:affiliation
Departments of Cardiology and Experimental Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
pubmed:publicationType
Journal Article