Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1978-12-20
|
| pubmed:abstractText |
Macrophage-migration inhibition factor (MIF) is a lymphocyte-derived substance which plays an important role in cell mediated immunity. Soluble factors containing MIF-like activity and produced by non-stimulated and virus-infected non-lymphoid cell cultures have also been reported. In the present study, a MIF-like factor was repeatedly detected in Buffalo green monkey kidney cells infected with mumps and herpes simplex virus type 1 (HSV-1) indicating that this substance is reproducible and can be stimulated by two viruses of widely varying groups. Wistar-38 (WI-38) cell cultures also increased production of this substance in response to mumps but not HSV-1 infection, indicating that the production of this factor is not necessarily induced by all viruses. A factor which stimulated the spread of macrophages was also found to be induced in WI-38 cells by both viruses, suggesting yet another substance produced by non-lymphoid cells in response to viral infection. The ability of non-stimulated WI-38 cells to produce MIF-like activity was also confirmed, and this factor could be further stimulated or opposed by viral infection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0091-7370
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
419-24
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:articleTitle |
MIF-like activity in non-stimulated and virus infected cell cultures.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|