Source:http://linkedlifedata.com/resource/pubmed/id/21299752
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2011-3-4
|
| pubmed:abstractText |
Previously we demonstrated profound effects of dopamine transporter (DAT) SLC6A3 genotype on limbic responses to smoking cues (SCs). Probands carrying at least one copy of the 9-repeat allele (9-repeat carriers) had greater neural responses to SCs in the anatomically interconnected rostral ventral striatum/medial orbitofrontal cortex (VS/mOFC), compared with homozygotes for the 10-repeat allele (10/10-repeats). To test the reliability of the initial findings, we examined perfusion functional magnetic resonance images acquired during SC exposure in a new cohort of smokers (N=26) who were genotyped for the SLC6A3 polymorphism. In smokers overall, activity was enhanced in the VS/mOFC (t=3.77). Contrasts between allelic groups revealed that 9-repeat carriers had a greater response to SCs in the VS (t=3.12) and mOFC (t=3.19). In separate groups, 9-repeat carriers showed increased activity in the VS (t=5.47) and mOFC (T=4.96), while no increases were observed in 10-repeats. Subjective reports of craving correlated with increased activity in reward-related structures including the extended amygdala, insula and post-central gyrus, and decreased activity in the dorsolateral prefrontal cortex, and were DAT-genotype dependent (r=0.63-0.96). In secondary analyses, we found that The Fagerström Test for Nicotine Dependence scores correlated with enhanced SC-induced perfusion in 10/10-repeats in the insula, mOFC, medial temporal and superior frontal gyri (r=0.50-0.82), while correlations were absent in 9-repeat carriers. Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1369-1600
|
| pubmed:author |
pubmed-author:BerrettiniWadeW,
pubmed-author:ChildressAnna RoseAR,
pubmed-author:CruzJeffreyJ,
pubmed-author:DetreJohn AJA,
pubmed-author:FranklinTeresa RTR,
pubmed-author:GoldmanMarinaM,
pubmed-author:HazanRebeccaR,
pubmed-author:JensWillW,
pubmed-author:LohoffFalk WFW,
pubmed-author:O'BrienCharles PCP,
pubmed-author:SuhJesse JJJ,
pubmed-author:WangZeZ,
pubmed-author:YinLiL
|
| pubmed:copyrightInfo |
© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
308-22
|
| pubmed:dateRevised |
2011-9-22
|
| pubmed:meshHeading |
pubmed-meshheading:21299752-Adolescent,
pubmed-meshheading:21299752-Adult,
pubmed-meshheading:21299752-Alleles,
pubmed-meshheading:21299752-Amygdala,
pubmed-meshheading:21299752-Basal Ganglia,
pubmed-meshheading:21299752-Brain Mapping,
pubmed-meshheading:21299752-Cerebral Cortex,
pubmed-meshheading:21299752-Cohort Studies,
pubmed-meshheading:21299752-Cues,
pubmed-meshheading:21299752-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:21299752-Female,
pubmed-meshheading:21299752-Frontal Lobe,
pubmed-meshheading:21299752-Genotype,
pubmed-meshheading:21299752-Heterozygote Detection,
pubmed-meshheading:21299752-Homozygote,
pubmed-meshheading:21299752-Humans,
pubmed-meshheading:21299752-Male,
pubmed-meshheading:21299752-Middle Aged,
pubmed-meshheading:21299752-Motivation,
pubmed-meshheading:21299752-Parietal Lobe,
pubmed-meshheading:21299752-Polymorphism, Genetic,
pubmed-meshheading:21299752-Prefrontal Cortex,
pubmed-meshheading:21299752-Smoking,
pubmed-meshheading:21299752-Smoking Cessation,
pubmed-meshheading:21299752-Tobacco Use Disorder,
pubmed-meshheading:21299752-Young Adult
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort.
|
| pubmed:affiliation |
Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA. franklin_t@mail.trc.upenn.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|