Homozygosity for glycine at codon 16 (GlyGly) of the ?(2)-adrenergic receptor may alter receptor sensitivity upon chronic stimulation and has been implicated in the pathogenesis of hypoglycaemia unawareness. We compared the effect of antecedent hypoglycaemia on ?(2)-adrenergic receptor sensitivity between GlyGly participants and those with arginine 16 homozygosity (ArgArg) for the ?(2)-adrenergic receptor.
The effect of antecedent hypoglycaemia on ??-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the ??-adrenergic receptor.
Department of Pharmacology-Toxicology 149, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, PO Box 9101, 6500HB Nijmegen, the Netherlands. b.schouwenberg@pharmtox.umcn.nl
