Source:http://linkedlifedata.com/resource/pubmed/id/21298140
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
|
| pubmed:dateCreated |
2011-3-16
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| pubmed:abstractText |
The nature of internal chiral diamines can greatly influence the ratio of helical diastereomers for Ni-salen based metallofoldamers. The diastereomer ratio is small for metallofoldamers derived from (1R, 2R)-cyclohexanediamine, (11R, 12R)-9,10-dihydro-9,10-ethanoanthracene-11,12-diamine, or (1R, 2R)-cyclopentanediamine. By contrast, the foldamer from (1S, 2S)-1,2-diphenylethylenediamine provides a relatively large bias (6 : 1) for the P-helical diastereomer as evidenced by NMR studies, chiroptical data, and X-ray studies. A model is proposed to explain the origin of the helical bias. These findings underscore the need to consider helical diastereomers in models for asymmetric induction in metal-salen catalyzed reactions.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1364-548X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
7
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| pubmed:volume |
47
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3781-3
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| pubmed:year |
2011
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| pubmed:articleTitle |
Interplay between the diamine structure and absolute helicity in Ni-salen metallofoldamers.
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| pubmed:affiliation |
Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19803, USA.
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| pubmed:publicationType |
Journal Article
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