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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-2-7
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pubmed:abstractText |
sAPP? released after ? secretase cleavage of Amyloid Precursor Protein (APP) has several functions including the stimulation of neurite outgrowth although detailed morphometric analysis has not been done. Two domains involved in this function have been described and are present in sAPP? released at the first step of amyloid peptide cleavage, raising the possibility that sAPP? could also stimulate neurite outgrowth. We investigated the morphological effects of sAPP? and sAPP? on primary neurons and identified a key signaling event required for the changes observed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-10026239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-10336659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-10421573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-10561492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-11224546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-11331872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-11441186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-1279136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-1402883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-15073156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-15385965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-1576957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-16407979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-17428603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-18362153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-18573216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-18585048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-18717733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-19225519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-19710311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-2087563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-7595508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-7913487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-8035204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-8158260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-8207383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-8505371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-8570096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-8863493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-8940123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-9354812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21298006-9440815
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e16301
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pubmed:meshHeading |
pubmed-meshheading:21298006-Amyloid beta-Protein Precursor,
pubmed-meshheading:21298006-Animals,
pubmed-meshheading:21298006-Axons,
pubmed-meshheading:21298006-Brain,
pubmed-meshheading:21298006-Cell Adhesion,
pubmed-meshheading:21298006-Cells, Cultured,
pubmed-meshheading:21298006-Dose-Response Relationship, Drug,
pubmed-meshheading:21298006-Early Growth Response Protein 1,
pubmed-meshheading:21298006-Mice,
pubmed-meshheading:21298006-Mice, Knockout,
pubmed-meshheading:21298006-Neurons,
pubmed-meshheading:21298006-Signal Transduction
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pubmed:year |
2011
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pubmed:articleTitle |
Secreted amyloid precursor protein ? and secreted amyloid precursor protein ? induce axon outgrowth in vitro through Egr1 signaling pathway.
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pubmed:affiliation |
INSERM U894, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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