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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-7
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pubmed:abstractText |
We established a novel dermatitis model in mice earlobes and analyzed the roles of histamine using specific antagonists for histamine receptors. After sensitization with picryl chloride (PiCl) by painting it on the earlobes of cyclophosphamide-treated mice, 12-O-tetradecanoylphorbol 13-acetate (TPA) was painted twice at the same site, and then allergic inflammation was induced by painting with PiCl. Histamine antagonists and cyclosporin A were administered i.v. The application of TPA shifted the PiCl-induced allergic inflammation from a delayed-type response to a biphasic response and increased the infiltration of eosinophils and mast cells at the inflammatory site. In this model, the PiCl-induced increase in the thickness of the earlobe in the immediate phase was suppressed by the histamine H? antagonist pyrilamine. In contrast, the increase in the swelling in the late phase and the infiltration of eosinophils were suppressed by the H?/H? antagonist thioperamide. The inhibitory effect of the combined treatment with pyrilamine and thioperamide on TPA-modified contact dermatitis was as potent as that of cyclosporin A. Histamine plays significant roles in early-phase swelling via H? receptors and in late-phase swelling via H?/H? receptors in this TPA-modified allergic dermatitis model.
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pubmed:language |
jpn
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Hrh4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Picryl Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrilamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H3,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/thioperamide
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0031-6903
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-84
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pubmed:meshHeading |
pubmed-meshheading:21297358-Animals,
pubmed-meshheading:21297358-Cyclosporine,
pubmed-meshheading:21297358-Dermatitis, Atopic,
pubmed-meshheading:21297358-Disease Models, Animal,
pubmed-meshheading:21297358-Drug Therapy, Combination,
pubmed-meshheading:21297358-Histamine,
pubmed-meshheading:21297358-Histamine Antagonists,
pubmed-meshheading:21297358-Humans,
pubmed-meshheading:21297358-Mice,
pubmed-meshheading:21297358-Picryl Chloride,
pubmed-meshheading:21297358-Piperidines,
pubmed-meshheading:21297358-Pyrilamine,
pubmed-meshheading:21297358-Receptors, G-Protein-Coupled,
pubmed-meshheading:21297358-Receptors, Histamine,
pubmed-meshheading:21297358-Receptors, Histamine H1,
pubmed-meshheading:21297358-Receptors, Histamine H3,
pubmed-meshheading:21297358-Tetradecanoylphorbol Acetate
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pubmed:year |
2011
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pubmed:articleTitle |
[Roles of histamine in the exacerbated allergic dermatitis].
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Tohoku University. hirasawa@mail.pharm.tohoku.ac.jp
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pubmed:publicationType |
Journal Article,
English Abstract,
Review
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